Volume 11, No 4, Dec 2001
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 11 Issue 4, December 2001: 317-320
COMMENTARY
Norepinephrine transporter (NET) is expressed in cardiac sympathetic ganglia of adult rat
LI He1, 2, Sun Kai MA1, Xiao Ping HU3, Gou Yuan ZHANG2, Jian FEI1,*
1Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
2Cardiovascular Division of Changzheng Hospital, Shanghai 200003, China E mail: h-li@hotmail.com
3Pathological Division of Pu Nan Hospital, Shanghai 200125, China
Correspondence:
The sympathetic nervous system plays a cardinal role in regulating cardiac function through releasing the neurotransmitter norepinephrine (NE). In comparison with central nervous system, the molecular mechanism of NE uptake in myocardium is not clear. In present study, we proved that in rat the CNS type of NE transporter (NET) was also expressed in middle cervical-stellate ganglion complex (MC-SG complex) which is considered to control the activity of heart, but not expressed in myocardium. The results also showed that NET expression level in right ganglion was significantly higher than in the left, rendering the greater capacity of NE uptake in right ventricle, a fact which may contribute to the maintenance of right ventricular function under pathologic state.
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