Volume 11, No 3, Sep 2001
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 11 Issue 3, September 2001: 165-180
REVIEWS
The angiotensin II type 1 receptor and receptor-associated proteins
GUO Deng Fu1, *, Yu lin SUN1, Pavel HAMET1, Tadashi INAGAMI2
1Research Centre, Hotel-Dieu of CHUM and Department of Medicine, University of Montreal, Montreal, Quebec, Canada H2W 1T8
2Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN, USA 37232-0146
Correspondence:
The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological actions of Ang II. Among the structures required for regulation and activation of the receptor, its carboxyl-terminal region plays crucial roles in receptor internalization, desensitization and phosphorylation. The mechanisms involved in heterotrimeric G-protein coupling to the receptor, activation of the downstream signaling pathway by G proteins and the Ang II signal transduction pathways leading to specific cellular responses are discussed. In addition, recent work on the identification and characterization of novel proteins associated with carboxyl-terminus of the AT1 receptor is presented. These novel proteins will advance our understanding of how the receptor is internalized and recycled as they provide molecular mechanisms for the activation and regulation of G-protein-coupled receptors.
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