Volume 10, No 4, Dec 2000

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 10 Issue 4, December 2000: 267-278

REVIEWS

Executionary pathway for apoptosis: lessons from mutant mice

WOO Minna*, Razqallah HAKEM, Tak W. MAK

Amgen Institute and Ontario Cancer Institute, Departments of Immunology and Medical Biophysics, University of Toronto, Canada Correspondence:

Apoptosis or programmed cell death (PCD) is an evolutionarily conserved cellular process that is essential for normal development and homeostasis of multicellular organisms. Defects in the apoptosis signaling result in many diseases including autoimmune diseases and cancer. The apoptosis signaling pathway was first described genetically in the nematode Caenorhabditis elegans which serves as a framework for the more complex apoptotic pathways that exist in mammals. In this review, we will discuss the apoptotic pathways that are emerging in mammals as elucidated by studies of gene-targeted mutant mice.

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