Volume 10, No 2, Jun 2000
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 10 Issue 2, June 2000: 115-125
ORIGINAL ARTICLES
The expression of glucose regulated protein-94 in colorectal carcinoma cells treated by sodium butyrate
WU Yi Di, Jin Dan SONG*
Key Laboratory of Cell Biology, Ministry of Public Health of China
Institute of Medical Molecular Biology, China Medical University, 92 Beier Rd. Heping District, Shenyang 110001, China
Correspondence:
The expression of glucose regulated protein 94 (GRP94) during the treatment of human colorectal carcinoma cell line-Clone A cells with sodium butyrate was studied. Sodium butyrate (SB) can cause functional and morphological effects on Clone A cells including growth arrest at G
0/G
1 stage and cell differentiation as observed by morphological changes, MTT and flow cytometry assays, as well as reduced Grp94 gene expression as shown by Northern blot and Western blot assays. The possible mechanism of the correlation between Grp94 gene expression and tumor growth inhibition and cell differentiation is briefly discussed.
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