Volume 9 Issue 4, December 1999: 315-325
ORIGINAL ARTICLES
Evidence for a mouse brain-specific variant of α-tubulin
KONG Ling Wei1, Xiao Yan DING2, Hiroshi KITANI3, Robert SHIURBA4, Nai He JING1,*
1. Shanghai Institute of Biochemistry, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
2. Shanghai Institute of Cell Biology, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
3. National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba 305, Japan
4. Misato Plaheat Mfg., Ltd., 521-18 Kamiuwada, Satte-shi, Saitama 340-0124, Japan
Correspondence:
While studying the neural precursor cell intermediate filament protein known as nestin in the developing mouse brain, we observed a strong cross-reaction of our nestin antibody with a 50 kDa protein that appeared on embryonic day 10 and continued to accumulate until postnatal day 1. Here we report evidence that this protein is a brain-specific variant form of α-tubulin and discuss its implications.
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