Volume 9 Issue 3, September 1999: 163-171
REVIEWS
Regulation of eukaryotic DNA replication and nuclear structure
WU Jia Rui
Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai 200031, China
e-mail: wujr@sunm.shcnc.ac.cn
Correspondence:
In eukaryote, nuclear structure is a key component for the functions of eukaryotic cells. More and more evidences show that the nuclear structure plays important role in regulating DNA replication. The nuclear structure provides a physical barrier for the replication licensing, participates in the decision where DNA replication initiates, and organizes replication proteins as replication factory for DNA replication. Through these works, new concepts on the regulation of DNA replication have emerged, which will be discussed in this minireview.
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