Volume 8, No 2, Jun 1998

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 8 Issue 2, June 1998: 159-165

LETTERS TO THE EDITOR

Antisense oligonucleotide to insulin-like growth factor II induces apoptosis in human ovarian cancer AO cell line.

Yin DL, Pu L, Pei G.

Shanghai Institute of Cell Biology, Chinese Academy of Sciences, China. Correspondence: Yin DL,

The effects of antisense oligonucleotide to insulin-like growth factor II (IGFII) to induce apoptosis in human ovarian cancer cells were evaluated. antiproliferation effects of antisense to IGFII in ovarian cancer AO cells were determined by 3H-thymidine incorporation. Apoptosis of the IGFII antisense-treated cells was quantitated by both nuclear condensation and flow cytometry after cells were stained with propidium iodide. IGFII antisense (4.5 microM) treatment of 48 h maximally inhibited proliferation of AO cells. More than 25% of IGFII antisense-treated cells (4.5 microM for 24 h) had undergone apoptosis, whereas less than 3% of the cells were apoptotic in either IGFII sense-treated cells or untreated cells. Antisense oligonucleotide to IGFII significantly inhibited cell proliferation and induced apoptosis in human ovarian cancer AO cell. These data suggest that IGFII may be a potential target in treatment of ovarian cancer and antisense oligonucleotide to IGFII may serve as a therapeutic approach.

FULL TEXT | PDF

Browse 1646