Volume 4 Issue 2, December 1994: 117-125
ORIGINAL ARTICLES
zpl, a new gene in drosophila required for neurogenesis
Zhao DeBiao, Serge COTE, Gans JurGens,Cabita Arora, Herbeart Jaeckle.
Shanghai Institute of Cell Biology, CHinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
Ontogenese et Genetique Moleculaires, CHUL, Quebec, Canada
Intitut fur Genetik und MIkrobiologie, Unifersitat Munchen, Maria=Ward-Str 1A, D-8000 Munchen 19, Germany
Correspondence:
zpl (zip-like) gene mutant embryos showed the cuticular defect with alternative denticle rows and a hole from head to abdomen. zpl mutants also caused the overgrowth of neural cells and axons both in CNS and PNS as well as the wrong pathway of neural fasciculation and the disappearance of hypophysis, as shown by whole mount embryos stained withantibody against HRP and MAb-22C10. Genetic analysis has protided evidence that zpl, located in the right arm ofthe second cliromosome (between 75 and 102 genetic map units), is a new gene closely related to the zip gene.
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