Volume 4 Issue 2, December 1994: 191-200
ORIGINAL ARTICLES
Preliminary evidence that overexpression of nuclearfactor for IL6 expression (NF-IL6) in NIH3T3 cells may berelated to malignant transformation
Zhu MinSheng, DingGan Liu, ShiZuo AKIRA, ZaiPIng Li
Shanghai Institute of Biochemistry, Academic Sinica, Shanghai 200031, China
Institute of Molecular and Cellular Biology, Osaka University, Japan.
Correspondence: DingGan Liu
NF-IL6 is a member of c/EBP family and has multiple functions in regulation of cellular gene expression. We have constructed NF-IL6 expression plasmids and trans fected the NIH3T3 cells with them. The sense NF-IL6 transfectants showed significantly increased tumorigenicity, and the stable integration of NF-IL6 cDNA into cellular DNA and its expression were demonstrated. Our results suggest that NF-IL6 may be related to tumorigenesis.
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