Volume 23, No 2, Feb 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 2, February 2013: 173-175
RESEARCH HIGHLIGHTS
ISG15 regulates IFN-γ immunity in human mycobacterial disease
Jun-Bao Fan1 and Dong-Er Zhang1,2,3
1Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
2Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA
3Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
Correspondence: Dong-Er Zhang(d7zhang@ucsd.edu)
Interferon-gamma (IFN-γ) is crucial for immunity against different pathogens due to its broad effects on the multiple arms of the immune system. The regulation of IFN-γ immunity is of extensive interest to research as well as practical activity for drug discovery. New evidence supports previous findings that ubiquitin-like protein ISG15 acts as an extracellular cytokine and promotes IFN-γ production, providing intriguing insights of the importance of ISG15 into the control of human mycobacterial disease.
Cell Research (2013) 23:173–175; doi:10.1038/cr.2012.133; published online 11 September 2012
FULL TEXT | PDF
Browse 2022
