Volume 23, No 2, Feb 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 2, February 2013: 176-178
RESEARCH HIGHLIGHTS
In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK)
Shigeo Masuda1, Mo Li1 and Juan Carlos Izpisua Belmonte1,2
1Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
2Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain
Correspondence: Juan Carlos Izpisua Belmonte(belmonte@salk.edu, izupisua@cmrb.eu)
Blood transfusion medicine requires a constant supply of platelets, which is now totally donor dependent. Recent advances in the generation of platelets in vitro through megakaryocytes (MKs) may provide protocols not only via pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), but also via induced MKs (iMKs). For the first time, mouse and human fibroblasts are successfully transdifferentiated into iMKs by the introduction of three factors, p45NF-E2, Maf G, and Maf K.
Cell Research (2013) 23:176–178; doi:10.1038/cr.2012.142; published online 9 October 2012
FULL TEXT | PDF
Browse 2299
