Volume 23, No 3, Mar 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 3, March 2013: 317-319

RESEARCH HIGHLIGHTS

Overcoming the chromatin barrier to end resection

Huan Chen¹ and Lorraine S Symington¹

¹Department of Microbiology & Immunology, Columbia University Medical Center, New York, NY 10032, USA Correspondence: lss5@columbia.edu(Lorraine S Symington,)

Repair of double-strand breaks by homologous recombination requires Repair of double-strand breaks by homologous recombination requires 5′-3′ resection of the DNA ends to create 3′ single-stranded DNA tails. While much progress has been made in identifying the proteins that directly participate in end resection, how this process occurs in the context of chromatin is not well understood. Two papers in Nature report that Fun30, a poorly characterized member of the Swi2/Snf2 family of chromatin remodelers, plays a role in end processing by facilitating the Exo1 and Sgs1-Dna2 resection pathways.

Cell Research (2013) 23:317–319; doi:10.1038/cr.2012.148; published online 13 November 2012

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