Volume 23, No 3, Mar 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 3, March 2013: 320-322
RESEARCH HIGHLIGHTS
Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein
Martin R Jakobsen1,2, Trine H Mogensen2,3 and Søren R Paludan1,2
1Department of Biomedicine, University of Aarhus, Aarhus, Denmark
2Aarhus Research Center for Innate Immunology, Aarhus University, Aarhus, Denmark
3Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
Correspondence: Søren R Paludan(srp@microbiology.au.dk)
Human immunodeficiency virus type 1 (HIV-1) is the cause of AIDS. In recent years it has emerged that cellular interferon-stimulated genes (ISG), play important roles in cell-intrinsic restriction of HIV replication. A publication now describes a novel strategy employed by HIV-infected cells to restrict viral replication, which involves inhibition of viral mRNA translation by the ISG Schlafen 11.
Cell Research (2013) 23:320–322; doi:10.1038/cr.2012.155; published online 6 November 2012
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