Volume 23, No 4, Apr 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 4, April 2013: 449-451

RESEARCH HIGHLIGHTS

LncRNAs have a say in protein translation

Maite Huarte

Regulation of Gene Expression Laboratory, Division of Oncology, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain Correspondence: (maitehuarte@unav.es)

In a recent paper published in Nature, Carrieri et al. have identified in mouse a neuron-specific antisense lncRNA transcribed in the opposite strand of Uchl1 mRNA. Antisense Uchl1 specifically promotes the translation of UCHL1 under rapamycin treatment. To do so, the lncRNA only requires a SINEB2 repeat and a small region with sequence complementarity to the regulated mRNA.

Cell Research (2013) 23:449–451. doi:10.1038/cr.2012.169; published online 4 December 2012

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