Volume 23, No 4, Apr 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 4, April 2013: 458-459
RESEARCH HIGHLIGHTS
Niche-less maintenance of HSCs by 2i
Shigeo Masuda1, Mo Li1 and Juan Carlos Izpisua Belmonte1,2
1Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
2Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain
Correspondence: Juan Carlos Izpisua Belmonte(belmonte@salk.edu, izpisua@cmrb.eu)
Maintenance of hematopoietic stem cells (HSCs) in vitro has been believed to be difficult due to a lack of complete understanding of HSC quiescence maintained by the niche. Recent evidence suggests that in vitro maintenance of human and mouse long-term HSCs (LT-HSCs) is possible through dual inhibition (2i) of both GSK-3 and mTOR in the absence of cytokines, serum, or feeder cells.
Cell Research (2013) 23:458–459. doi:10.1038/cr.2013.14; published online 29 January 2013
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