Volume 23, No 4, Apr 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 4, April 2013: 463-464
RESEARCH HIGHLIGHTS
Unspliced XBP1 controls autophagy through FoxO1
Rene L Vidal1 and Claudio Hetz1,2,3
1Neurounion Biomedical Foundation, University of Chile, Santiago, Chile
2Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile
3Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile
Correspondence: Claudio Hetz Rene L Vidal(chetz@med.uchile.cl rene.vidal@neurounion.com)
Protein homeostasis in higher eukaryotes is balanced by a dynamic network of adaptive mechanisms, including the unfolded protein response (UPR) and autophagy. In a paper recently published in Cell Research, Zhu and co-workers uncover a novel biological function of the unspliced form of the UPR transcription factor XBP1 in the modulation of autophagy through the control of FoxO1 turnover.
Cell Research (2013) 23:463–464. doi:10.1038/cr.2013.9; published online 22 January 2013
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