Volume 23, No 5, May 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 5, May 2013: 585-587

RESEARCH HIGHLIGHTS

DNA sensing unchained

Andrea Ablasser¹ and Veit Hornung¹

¹Institute for Clinical Chemistry and Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Germany Correspondence: Veit Hornung,(veit.hornung@uni-bonn.de)

In two recent reports in Science, James Chen and colleagues provide compelling evidence that detection of cytosolic DNA triggers the production of a novel second messenger, cyclic GMP-AMP (cGAMP), which in turn activates a signaling pathway that induces type I interferons (IFNs) in a STING-dependent manner. They further unravel a key role for a so far uncharacterized murine protein E330016A19 (human homolog: C6ORF150), now termed cGAMP synthetase (cGAS), to act as the DNA sensor that generates cGAMP.

Cell Research (2013) 23:585–587. doi:10.1038/cr.2013.28; published online 19 February 2013

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