Volume 23, No 5, May 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 5, May 2013: 592-594
RESEARCH HIGHLIGHTS
hESC-derived pancreatic progenitors
Lina Sui1, Guang-Hui Liu1 and Juan Carlos Izpisua Belmonte2,3
1National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
2Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
3Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain
Correspondence: Guang-Hui Liu Juan Carlos Izpisua Belmonte(ghliu@ibp.ac.cn; belmonte@salk.edu, izpisua@cmrb.eu)
Successful derivation of pancreatic progenitors from human embryonic stem cells (hESCs) in vitro and further differentiation towards functional β cells in vivo may create the possibility of using hESC-derived pancreatic progenitors (PPs), instead of derived β cells, as an alternative transplantable source in β cell replacement therapy. Here we discuss present approaches, as well as future alternatives, in the fields of basic and clinic research on β cell differentiation, derivation and transplantation.
Cell Research (2013) 23:592–594. doi:10.1038/cr.2013.20; published online 5 February 2013
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