Volume 23, No 5, May 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 5, May 2013: 595-596
RESEARCH HIGHLIGHTS
Love and death: microglia, NLRP3 and the Alzheimer's brain
Tobias Goldmann1, Tuan Leng Tay1 and Marco Prinz1,2
1Institute of Neuropathology, University of Freiburg, Germany
2BIOSS Center for Biological Signalling, University of Freiburg, Germany
Correspondence: Marco Prinz(marco.prinz@uniklinik-freiburg.de)
Microglia were previously attributed to be vital brain guardians for neuronal survival and synaptic pruning during development as well as for the brain's fight against environmental pathogens. A new report in Nature by the Heneka, Latz and Golenbock groups, however, sheds new light on these distinct myeloid cells by revealing their deadly nature for mature neurons during neurodegeneration.
Cell Research (2013) 23:595–596. doi:10.1038/cr.2013.24; published online 12 February 2013
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