Volume 23, No 5, May 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 5, May 2013: 597-598

RESEARCH HIGHLIGHTS

Proteasome-independent p53 degradation

Mais M Nuaaman¹ and Samuel Benchimol¹

¹Department of Biology, York University, Toronto, ON M3J 1P3, Canada Correspondence: Samuel Benchimol(benchimo@yorku.ca)

The intracellular levels of the p53 tumor suppressor protein are regulated through various pathways and involve numerous regulatory components. A recent study published in Cell Research identifies a proteasome-independent pathway of p53 protein degradation in the nucleolus that is dependent on Def and Calpain3.

Cell Research (2013) 23:597–598. doi:10.1038/cr.2013.38; published online 12 March 2013

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