Volume 15, No 11-12, Nov 2005
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 15 Issue 11-12, November 2005: 953-961
REVIEWS
Snapshot of HIV pathogenesis in China
Nitin K SAKSENA1, Bin WANG1, Megan STEAIN1, Rong Ge YANG2 and Lin Qi ZHANG3,4,5
1Retroviral Genetics Division, Centre for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead NSW 2145 Sydney, Australia
2AIDS and HIV Research Group, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
3Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10021, USA
4Modern Virology Research Center and AIDS Center, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
5The AIDS Research Center, Chinese Academy of Medical Sciences, Peking Union Medical School, Beijing 100730, China
Correspondence: Nitin K SAKSENA(Nitin_saksena@wmi.usyd.edu.au.)
Several reviews have focused on the nature of HIV infection and its spread in various geographical regions of China. In contrast, this review provides a comprehensive update on the prevalence of multiple HIV-1 subtypes, consequent emergence of recombinant and novel forms of HIV-1 in China, and the implications this may have on HIV diversity and the development of effective vaccines. In addition it also examines the dissemination of primary drug resistance in therapy naïve patients, as well as co-infections with two other important viruses-hepatitis B and C. The main purpose of this review is to provide a current snapshot of HIV-1 pathogenesis in China and possibly shed some light on the future of HIV evolution, and potential challenges for future vaccine and anti-retroviral therapeutics against HIV strains in this area.
Cell Research, 2005 15: 953–961 doi:10.1038/sj.cr.7290373
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