Volume 3 Issue 1, January 1993: 27-37
ORIGINAL ARTICLES
Nuclear localization of Sindbis virus nonstructural protein nsP2
Xiaozhong Wang and Mingxiao Ding
Department of Biology, Bering University, Beijing 100871, China
Correspondence:
In early infection, approximately 10% of nonstructural protein nsP2 of Sindbis virus was transported into the nuclei of virus-infected BHK-21 cells. Nuclear nsP2 was dominantly associated with nuclear matrix. During the course of infection, increasing amounts of nsP2 accumulated in the nuclear fraction. A prominent accumulation of nuclear nsP2 occurred early in infection, from 1 h to 3 h postinfection. Meanwhile, a weak NTPase activity was found to be associated with the immunocomplexed nsP2. Nuclear localization of nsP2 and its possible role were discussed in relation to the inhibition of host macromolecular synthesis.
Cell Res 3: 27-37; doi:10.1038/cr.1993.4
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