Volume 1 Issue 2, December 1990: 217-220
ORIGINAL ARTICLES
Studies on the mitogenic effect of transferrin by membrane signal transduction
TM Leung1, PL Lim2 and TT Loh1,3
1Department of Physiology, Medical Faculty, University of Hong Kong, Hong Kong
2Departwent of Microbiology, Medical Faculty, University of Hong Kong, Hong Kong
3To whom all correspondence should be addressed.
Correspondence:
One of the earliest events leading to cell activation and growth is the hydrolysis of inositol phospholipids producing various membrane signals induced by an interaction between growth factors or hormones with their respective receptors on the cell membrane 1. To demonstrate the mitogenic action of transferrin, our results show that an addition of transferrin to “serum–deprived” rat hepatoma cells produced a rapid but transient rise in inositol 1, 4, 5-trisphosphate (IP3) level, and at the same time, an increased intracellular Ca2+ activity and a cytoplasmic alkalinization were observed. These signal transduotions further lend support to the mitogenic nature oftransferrin. In addition, a possible link betwagn the receptor–mediated endocytosis of transferrin with the generation of intracellular signals is discussed herewith
Cell Res 1: 217-220; doi:10.1038/cr.1990.22
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