Volume 23, No 6, Jun 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 6, June 2013: 735-736

RESEARCH HIGHLIGHTS

Viral counterattack against the host innate immune system

Bin Wu^1,2 and Sun Hur^1,2

¹Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
²Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA Correspondence: Sun Hur(hur@idi.harvard.edu)

Paramyxoviruses evade antiviral immune response using a small nonstructural protein, V, which binds to the host dsRNA sensor MDA5 and prevents it from activating the interferon signaling pathway. A recent crystal structure of the V protein in complex with MDA5, published in Science, revealed that V disrupts the structure of MDA5 and is integrated into the MDA5 protein fold, providing an intriguing new example of viral mimicry as a countermeasure against the host immune system.

10.1038/cr.2013.32

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