Volume 23, No 6, Jun 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 6, June 2013: 737-738

RESEARCH HIGHLIGHTS

Unwinding the Wnt action of Casein Kinase1

Daniel GR Yim^1,2 and David M Virshup¹

¹Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School Singapore, Singapore
²Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore Correspondence: David M Virshup(david.virshup@duke-nus.edu.sg)

The casein kinase 1 (CK1) family, a major intracellular serine/threonine kinase, is implicated in multiple pathways; however, understanding its regulation has proven challenging. A recent study published in Science identifying allosteric activation of CK1 by the DEAD-box RNA helicase DDX3 expands our understanding of the control of this abundant kinase family.

10.1038/cr.2013.51

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