Volume 23, No 6, Jun 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 6, June 2013: 739-740

RESEARCH HIGHLIGHTS

Engaging the p53 metabolic brake drives senescence

Dadi Jiang¹ and Laura D Attardi^1,2

¹Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
²Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA Correspondence: Laura D Attardi(attardi@stanford.edu)

Emerging evidence suggests that the ability of p53 to regulate metabolism is important for its tumor suppressor activity. A recent study published in Nature reveals a novel connection between p53 and metabolism: p53 transcriptionally represses the expression of malic enzymes and associated NADPH production, which in turn triggers a positive feedback loop resulting in sustained p53 activation, cellular senescence, and tumor suppression.

10.1038/cr.2013.34

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