Volume 23, No 6, Jun 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 6, June 2013: 741-743

RESEARCH HIGHLIGHTS

The FBW7-KLF2 axis regulates endothelial functions

Yongchao Zhao1 and Yi Sun¹

¹Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA Correspondence: Yi Sun, Tel: 734-615-1989; Fax: 734-763-1581(sunyi@umich.edu)

FBW7 tumor suppressor suppresses the growth and survival of tumor cells by promoting the degradation of several oncoproteins, and induces endothelial differentiation by modulating the NF1/RAS axis. A recent study published in Cell Research showed that FBW7 further regulates endothelial functions via degrading transcription factor KLF2.

10.1038/cr.2013.50

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