Volume 23, No 7, Jul 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 7, July 2013: 870-871

RESEARCH HIGHLIGHTS

Set them free: F-box protein exchange by Cand1

Karin Flick¹ and Peter Kaiser¹

¹Department of Biological Chemistry, School of Medicine, University of California Irvine, 240D Med Sci I, Irvine, CA 92697-1700, USA Correspondence: Peter Kaiser, Tel: +1-(949) 824-9442; Fax: +1-(949) 824-2688(pkaiser@uci.edu)

Cand1 (Cullin-associated and neddylation-dissociated protein 1) has long been known as a regulator of SCF ubiquitin ligases, but details remained puzzling due to conflicting results from in vitro and in vivo experiments. Three recent reports, one in Cell and two in Nature Communications, propose Cand1 as a protein exchange factor with interesting mechanism that reconciles Cand1 genetics and biochemistry.

10.1038/cr.2013.55

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