Volume 23, No 8, Aug 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 8, August 2013: 973-974
RESEARCH HIGHLIGHTS
The CXXC-TET bridge — mind the methylation gap!
Donncha S Dunican1, Sari Pennings2 and Richard R Meehan1
1MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK
2Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
Correspondence: Richard R Meehan(Richard.Meehan@igmm.ed.ac.uk)
CG-rich DNA “reader” proteins that bind non-methylated CpG sequences have emerged as critical factors to the process of cell differentiation and development. In a recent paper in Nature, Ko et al. show that the CXXC domain protein, IDAX, plays a crucial role as a CG-rich DNA-binding factor in the regulation of Ten-Eleven-Translocation 2 (TET2) protein function.
10.1038/cr.2013.71
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