Volume 23, No 8, Aug 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 8, August 2013: 980-981
RESEARCH HIGHLIGHTS
RhoGTPases — NODes for effector-triggered immunity in animals
Lynda M Stuart1,2 and Laurent Boyer3
1Developmental Immunology and Center for Computational and Integrative Biology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA
2The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
3INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire, C3M, Toxines Microbiennes dans la relation hôte pathogènes, Nice, F-06204, France
Correspondence: Lynda M Stuart(lstuart@partners.org)
A recent study published in Nature by Keestra and colleagues addresses how the immune system detects the pathogenic potential of microbes and provides evidence that one strategy involves NOD1, which monitors the activation state of the RhoGTPases that are targeted by virulence effectors produced by pathogenic microbes. Interestingly, their findings reveal striking similarities with previous observations made in flies and plants, establishing the evolutionary conservation of this detection system in the innate immune arsenal in many taxa.
10.1038/cr.2013.68
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