Volume 23, No 8, Aug 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 8, August 2013: 982-983

RESEARCH HIGHLIGHTS

Ras and macropinocytosis: trick and treat

Fried J T Zwartkruis¹ and Boudewijn M T Burgering¹

¹Molecular Cancer Research, Centre for Biomedical Genetics and Cancer Genomics Centre, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands Correspondence: Fried J T Zwartkruis, E-mail: G.J.T.Zwartkruis@umcutrecht.nl; Boudewijn M T Burgering,(B.M.T.Burgering@umcutrecht.nl)

Oncogene-driven adaptation of metabolism during tumorigenesis includes steps that stimulate the uptake of nutrients, especially glucose and glutamine, to sustain cell growth and proliferation. Macropinocytosis, a clathrin- and caveolin-independent endocytotic process that had previously been linked to the action of oncogenic Ras and Src, is now shown to contribute to amino acid uptake via enhanced delivery of extracellular proteins to lysosomes.

10.1038/cr.2013.79

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