Volume 23, No 8, Aug 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 8, August 2013: 984-985

RESEARCH HIGHLIGHTS

ROS sets the stage for macrophage differentiation

Anthony Covarrubias¹, Vanessa Byles¹ and Tiffany Horng¹

¹Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA Correspondence: Correspondence: Tiffany Horng, E-mail: thorng@hsph.harvard.edu

While M1 macrophages are highly pro-inflammatory and microbicidal, M2 macrophages and the related tumor associated macrophages (TAMs) regulate tissue remodeling and angiogenesis and can display immunomodulatory activity. In July issue of Cell Research, Zhang et al. show that ROS production, critical for the activation and functions of M1 macrophages, is necessary for the differentiation of M2 macrophages and TAMs, and that antioxidant therapy blocks TAM differentiation and tumorigenesis in mouse models of cancer.

10.1038/cr.2013.88

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