Volume 23, No 9, Sep 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 9, September 2013: 1065-1066

RESEARCH HIGHLIGHTS

Building unique bonds to fight misplaced DNA

Caio T Fagundes¹ and Luke A J O‘Neill¹

¹School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland Correspondence: Luke A J O‘Neill, Tel: +353-1-896-1851(laoneill@tcd.ie)

A cyclic dinucleotide comprised of GMP and AMP was previously shown to be a key intermediate during activation of innate immune responses to cytosolic DNA. A report by Patel and Tuschl groups published in Cell reveals the structure of the enzyme involved in the synthesis of this second messenger and identifies this cyclic dinucleotide as a unique compound in metazoan cell signaling.

10.1038/cr.2013.81

FULL TEXT | PDF

Browse 2014