Volume 23, No 9, Sep 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 9, September 2013: 1067-1068

RESEARCH HIGHLIGHTS

Channel gating pore: a new therapeutic target

Polina Kornilov¹, Asher Peretz¹ and Bernard Attali¹

¹Department of Physiology & Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel Correspondence: Correspondence: Bernard Attali, Tel: 972-3640-5116; Fax: 972-3640-9113 E-mail: battali@post.tau.ac.il

Each subunit of voltage-gated cation channels comprises a voltage-sensing domain and a pore region. In a paper recently published in Cell Research, Li et al. showed that the gating charge pathway of the voltage sensor of the KCNQ2 K+ channel can accommodate small opener molecules and offer a new target to treat hyperexcitability disorders.

10.1038/cr.2013.89

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