Volume 23, No 9, Sep 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 9, September 2013: 1073-1074

RESEARCH HIGHLIGHTS

Sirtuins as therapeutic targets of ALS

Giulio Maria Pasinetti^1,2, Amanda E Bilski¹ and Wei Zhao^1,2

¹Department of Neurology, Mount Sinai School of Medicine, 1468 Madison Avenue, Annenberg Building, Room 20-02, New York, NY 10029, USA
²GRECC, James J Peters Veterans Affairs Medical Center, Bronx, NY, USA Correspondence: Giulio Maria Pasinetti, Tel: +1-212-241-7938 or +1-212-241-5563 Fax: +1-212-876-9042(Giulio.Pasinetti@mssm.edu)

Sirtuins have received a lot of attention in biological functions associated with metabolism, survival development, and most recently, neurodegeneration. The versatile role of sirtuins can be readily redirected for drug discovery studies for novel treatment in amyotrophic lateral sclerosis (ALS), as presented in this highlight, by sirtuin-mediated ketogenic responses influencing mitochondrial function.

10.1038/cr.2013.94

FULL TEXT | PDF

Browse 1962