Volume 23, No 10, Oct 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 10, October 2013: 1153-1154
RESEARCH HIGHLIGHTS
Directing transcription to the right way
Fu Huang1 and Jerry L Workman1
1Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
Correspondence: Jerry L Workman(jlw@stowers.org)
How cells ensure that productive transcription from divergent promoters is limited to the downstream protein-coding region is an important question in the transcription field. A recent study in Nature proposed an answer by revealing that the upstream antisense transcripts undergo early termination through the polyadenylation signal-dependent pathway, and the downstream sense transcripts are protected from premature cleavage by U1 small nuclear ribonucleoprotein (snRNP).
10.1038/cr.2013.100
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