Volume 23, No 10, Oct 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 10, October 2013: 1155-1156

RESEARCH HIGHLIGHTS

Pills of PTEN? In and out for tumor suppression

Antonella Papa¹, Ming Chen¹ and Pier Paolo Pandolfi¹

¹Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA Correspondence: Pier Paolo Pandolfi(ppandolf@bidmc.harvard.edu)

The tumor-suppressive activity of PTEN has always been attributed to its endogenous intracellular function. Recently two different groups have demonstrated that PTEN is secreted/exported into the extracellular environment for uptake by recipient cells, and functions as a tumor suppressor in a cell non-autonomous manner.

10.1038/cr.2013.103

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