Volume 23, No 10, Oct 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 10, October 2013: 1157-1158
RESEARCH HIGHLIGHTS
EGFR gets in the way of microRNA biogenesis
Naohiro Nishida1,2, Koshi Mimori3, Masaki Mori2 and George A Calin1
1Department of Experimental Therapeutics and The Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
2Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita City, Osaka, Japan
3Department of Surgery, Kyushu University Beppu Hospital, 4546 Tsurumibaru, Beppu, Oita, Japan
Correspondence: Correspondence: George A Calin, Tel: +1-713-792-5461; Fax: +1-713-745-4528 E-mail: gcalin@mdanderson.org
Recent studies suggest that microRNA (miRNA) processing is a key regulatory step in the miRNA biogenesis as well as its transcriptional control. In a paper recently published in Nature, Shen et al. revealed that epidermal growth factor receptor (EGFR) directly interacts with argonaute 2 (AGO2), a critical component of RNA-induced silencing complex (RISC), and inhibits the maturation of specific tumor suppressive miRNAs under hypoxic condition.
10.1038/cr.2013.87
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