Volume 23, No 10, Oct 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 10, October 2013: 1159-1160

RESEARCH HIGHLIGHTS

New hope for therapy in neurodegenerative diseases

Maria do Carmo Costa¹ and Henry L Paulson¹

¹Department of Neurology, University of Michigan, A. Alfred Taubman Medical Research Institute, Ann Arbor, MI 48109-2200, USA Correspondence: Henry L Paulsona, Tel: +1-734-615-6156; Fax: +1-734-615-5655 E-mail: henryp@umich.edu; Maria do Carmo Costab, Tel: +1-734-615-6156; Fax: +1-734-615-5655 E-mail: mariadoc@umich.edu;(costa.carmo@gmail.com)

The use of genetic screens to define cellular pathways that regulate neurodegenerative disease proteins has emerged as a powerful strategy to identify potential therapeutic targets for these disorders. Using cross-species genetic screens, Park et al. recently identified RAS-MAPK-MSK1 as a cellular pathway that modulates levels of the polyglutamine-containing protein ATXN1 and its subsequent toxicity in SCA1.

10.1038/cr.2013.96

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