Volume 23, No 10, Oct 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 10, October 2013: 1201-1214

ORIGINAL ARTICLES

A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity

Tong Guo^1,*, Yi Lu^1,*, Peixue Li¹, Meng-Xin Yin¹, Dekang Lv¹, Wenjing Zhang¹, Huizhen Wang¹, Zhaocai Zhou¹, Hongbin Ji¹, Yun Zhao¹ and Lei Zhang¹

¹State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China Correspondence: Lei Zhang, E-mail: rayzhang@sibcb.ac.cn; Yun Zhao,(yunzhao@sibcb.ac.cn)

The Hippo (Hpo) pathway controls tissue growth and organ size by regulating the activity of transcriptional co-activator Yorkie (Yki), which associates with transcription factor Scalloped (Sd) in the nucleus to promote downstream target gene expression. Here we identify a novel protein Sd-Binding-Protein (SdBP)/Tgi, which directly competes with Yki for binding to Sd through its TDU domains and inhibits the Sd-Yki transcriptional activity. We also find that SdBP retains Yki in the nucleus through the association with Yki WW domains via its PPXY motifs. Collectively, we identify SdBP as a novel component of the Hpo pathway, negatively regulating the transcriptional activity of Sd-Yki to restrict tissue growth.

10.1038/cr.2013.120

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