Volume 23, No 10, Oct 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 10, October 2013: 1237-1240

LETTERS TO THE EDITOR

Coordinated regulation of AMPK activity by multiple elements in the α-subunit

Feng-Jiao Xin^1,*, Jue Wang^1,*, Rong-Qing Zhao¹, Zhi-Xin Wang¹ and Jia-Wei Wu¹

¹MOE Key Laboratory of Protein Science and Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China Correspondence: Jia-Wei Wu, Tel: 86-10-62789387; Fax: 86-10-62792826(jiaweiwu@mail.tsinghua.edu.cn)

The AMP-activated protein kinase (AMPK) is the key energy sensor in response to various stresses that decrease cellular ATP levels, including low glucose, hypoxia, ischemia and heat shock. Recently, evidence has suggested that AMPK also plays critical roles in coupling the cellular bio-energetic state to various physiological processes, such as tumor suppression, cell polarity, life span, circadian clock, gene transcription and autophagy.

10.1038/cr.2013.121

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