Volume 23, No 11, Nov 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 11, November 2013: 1244-1246

RESEARCH HIGHLIGHTS

MeCP2: Making sense of missense in Rett syndrome

Abhishek Banerjee¹, Esmeralda Romero-Lorenzo¹ and Mriganka Sur¹

¹The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Correspondence: Mriganka Sur, Tel: +1 617-253-8784(msur@mit.edu)

Fine scale genomic regulation is critical for maintaining genomic integrity and is often disrupted in neurodevelopmental disorders. An intriguing new study reveals the intricate biochemical complexity of de novo post-translational modifications of MeCP2, including activity-dependent protein-protein interactions that 'bridge' the nuclear receptor co-repressor (NCoR) complex to chromatin and lead to alterations in gene expression that characterize Rett syndrome.

10.1038/cr.2013.109

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