Volume 23, No 11, Nov 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 11, November 2013: 1251-1253

RESEARCH HIGHLIGHT

Plk1: unexpected roles in DNA replication

Ranadip Mandal¹ and Klaus Strebhardt¹

¹Department of Gynecology and Obstetrics, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany Correspondence: Klaus Strebhardt, Tel: +49-69-6301-6894; Fax: +49-69-6301-6364(strebhardt@em.uni-frankfurt.de)

FOR20, a conserved centrosomal protein, is essential for Plk1 to localize to the centrosome during the S phase and regulate DNA replication. The absence of either Plk1 or FOR20 can stall the cell cycle by a previously unknown intra-S phase centrosomal checkpoint.

10.1038/cr.2013.130

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