Volume 23, No 12, Dec 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 12, December 2013: 1337-1338
RESEARCH HIGHLIGHTS
A chemical logic for reprogramming to pluripotency
Alejandro De Los Angeles1,2,3,4 and George Q Daley1,2,3,4
1Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
3Broad Institute, Boston, MA 02115, USA
4Harvard Stem Cell Institute, Boston, MA 02115, USA
Correspondence: George Q Daley(george.daley@childrens.harvard.edu)
Pluripotency can be experimentally induced from somatic cells by nuclear transfer, fusion with embryonic stem cells, or ectopic transcription factor induction, but attempts to recapitulate this process by chemical means alone have previously failed. In a recent paper published in Science, Hou et al. pursue a rational, albeit laborious approach to identify cocktails of small molecules whose treatment restores pluripotency in adult somatic cells.
10.1038/cr.2013.119
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