Volume 23, No 12, Dec 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 12, December 2013: 1339-1340

RESEARCH HIGHLIGHTS

Metabolites from intestinal microbes shape Treg

Markus B Geuking1, Kathy D McCoy¹ and Andrew J Macpherson¹

¹University of Bern, Maurice Müller Laboratories (DKF), University Clinic for Visceral Surgery and Medicine, Murtenstrasse 35, CH-3010 Bern, Switzerland Correspondence: Andrew J Macpherson, Tel: +41 31 632 8025(andrew.macpherson@insel.ch)

Intestinal bacterial metabolites are an important communication tool between the host immune system and the commensal microbiota to establish mutualism. In a recent paper published in Science, Wendy Garrett and her colleagues report an exciting role of the three most abundant microbial-derived short-chain fatty acids (SCFA), acetic acid, propionic acid and butyric acid, in colonic regulatory T cell (cTreg) homeostasis.

10.1038/cr.2013.125

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