Volume 23, No 12, Dec 2013
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 23 Issue 12, December 2013: 1341-1342
RESEARCH HIGHLIGHTS
Common and divergent functions of Beclin 1 and Beclin 2
Lorenzo Galluzzi1,2,3 and Guido Kroemer2,3,4,5,6
1Gustave Roussy, Villejuif, France
2Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France
3Equipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
4INSERM, U848, Villejuif, France
5Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France
6Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France
Correspondence: Guido Kroemer, Tel: +33 1 4211 4516; Fax: +33 1 4211 6047 E-mail: kroemer@orange.fr; Lorenzo Galluzzi, Tel: +33 1 4211 6046; Fax: +33 1 4211 6047(deadoc@vodafone.it)
In a recent paper published in Cell, He and colleagues reported the identification and functional characterization of Beclin 2, a mammal-specific homolog of the evolutionarily conserved autophagy-regulatory and oncosuppressive factor Beclin 1. In spite of a non-negligible degree of sequence identity, Beclin 1 and Beclin 2 differ from each other in multiple aspects, including their functional profile as well as the genomic organization of the respective loci.
10.1038/cr.2013.129
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