Volume 23, No 12, Dec 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 12, December 2013: 1420-1423

LETTERS TO THE EDITOR

Proliferation and differentiation of mouse embryonic stem cells lacking all lamins

Youngjo Kim1, Xiaobin Zheng¹ and Yixian Zheng¹

¹Carnegie Institution for Science, 3520 San Martin Dr., Baltimore, MD 21218 USA Correspondence: Yixian Zheng, Tel: +1-410-246-3032; Fax: +1-410-243-6311(zheng@ciwemb.edu)

Lamins are the major components of the nuclear lamina (NL), which is located underneath the inner nuclear membrane1. Diverse array of functions have been assigned to lamins, and alterations of lamins are associated with a number of human diseases2. Of the three lamin genes in mammals, Lmna expresses all isoforms of A-type lamins, referred to as lamin-A/C, through alternative splicing, while Lmnb1 and Lmnb2 express B-type lamins. Despite subtype-specific sequence variations and different expression patterns, lamin proteins exhibit overall sequence similarity. Therefore, a potential functional redundancy among different lamin proteins has made it difficult to precisely address the role of lamins in mammals.

10.1038/cr.2013.118

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