Volume 24, No 1, Jan 2014

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 24 Issue 1, January 2014: 3-4

RESEARCH HIGHLIGHTS

Control of the hematopoietic stem cell state

David JHF Knapp¹ and Connie J Eaves¹

¹Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada V5Z 1L3 Correspondence: Connie J Eaves(ceaves@bccrc.ca)

Several studies have demonstrated the clonal transmission of distinct differentiation and self-renewal properties in hematopoietic stem cells during the regeneration of blood production in transplanted recipients. A recent publication now identifies Vwf expression as a discriminating marker of a hematopoietic stem cell state that is primed for platelet production in response to thrombopoietin, but also subject to developmental and other, as yet undefined, cues.

10.1038/cr.2013.139

FULL TEXT | PDF

Browse 2160