Volume 24, No 2, Feb 2014
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 24 Issue 2, February 2014: 137-138
RESEARCH HIGHLIGHTS
Discovering the Hippo pathway protein-protein interactome
Iván M Moya1,2 and Georg Halder1,2
1VIB Center for the Biology of Disease, University of Leuven, 3000 Leuven, Belgium
2KU Leuven Center for Human Genetics, University of Leuven, 3000 Leuven, Belgium
Correspondence: Georg Halder,(Georg.Halder@vib.be)
The Hippo pathway is a signal transduction pathway that regulates organ growth, stem cell biology, regeneration and cancer. Three recent proteomic studies with Hippo pathway components uncovered extensive networks of interacting proteins revealing novel connections to cell-cell junctions, regulation by vesicle trafficking, and phosphorylation-dependent remodeling of the interactome, and provide a rich landscape of novel interactors ripe for mechanistic studies.
10.1038/cr.2014.6
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