Volume 24, No 2, Feb 2014
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 24 Issue 2, February 2014: 139-140
RESEARCH HIGHLIGHTS
MLKL regulates necrotic plasma membrane permeabilization
Lorenzo Galluzzi1,2,3, Oliver Kepp3,4,5 and Guido Kroemer2,3,4,5,6
1Gustave Roussy, Villejuif, France
2Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France
3Equipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
4INSERM, U848, Villejuif, France
5Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France
6Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France
Correspondence: Lorenzo Galluzzi, E-mail: deadoc@vodafone.it; Guido Kroemer,(kroemer@orange.fr)
Recent data from two independent laboratories have shed new light on the molecular mechanisms by which mixed lineage kinase domain-like (MLKL) promotes a peculiar form of regulated necrosis known as necroptosis. Upon phosphorylation by receptor-interacting protein kinase 3 (RIPK3), MLKL appears indeed to form oligomers that localize to the plasma membrane and compromise its ability to preserve ionic homeostasis.
10.1038/cr.2014.8
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